THE FEVER TREE: FROM MALARIA TO NEUROLOGICAL DISEASES

The Fever Tree: from Malaria to Neurological Diseases

This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine.Since the introduction of cinchona to Europe in the 17th century, it played a role in treating emperors and peasants and was central to colonialism and wars.Over those 400 years, the medical use of c

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CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer

Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths globally.Immune checkpoint blockade (ICB) has transformed cancer medicine, with anti-programmed cell death protein 1 (anti-PD-1) therapy now well-utilized for treating NSCLC.Still, not all patients with NSCLC respond positively to anti-PD-1 therapy, and some patient

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Socioeconomic development evaluation for Chinese poverty-stricken counties using indices derived from remotely sensed data

Comprehensively and objectively evaluating the development of poverty-stricken counties is important for poverty alleviation.In this study, we propose a relatively objective and efficient method that utilizes indicators derived from remote sensing images to assess the socioeconomic development HOMME PURETE SHAMPOO of poverty-stricken counties.Four

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